Research in the Zanda group integrates synthetic/bioorganic/medicinal chemistry with translational biomedical research and molecular imaging technologies, particularly Positron Emission Tomography (PET) with applications in brain imaging, cardiovascular and oncology.
As a recent example, we reported the first synthesis of the fungal metabolite YWA1 and several functional constructs carrying biotin, Oregon green and the fluorescent dye PyMPO, which are useful tools for studying the biology of pathogenic Aspergillus fungi, with the view of developing diagnostics and therapeutics for fungal infections (https://doi.org/10.1021/acs.joc.0c02324). The project is a collaboration with the group of Prof Gordon Brown at the MRC Centre for Medical Mycology, University of Exeter (UK) https://www.exeter.ac.uk/medicalmycology/team/.
We also have a special interest in organofluorine chemistry and novel methodologies in bioorthogonal chemistry. For example, we developed a novel strategy for the conjugation of trans-cyclooctene (TCO) derivatives to a biomolecule, by exploiting the potential of trans,trans-cyclooctadiene (E,E-COD) (https://doi.org/10.1021/acs.bioconjchem.0c00375). Bovine serum albumin was labelled with bifunctional linkers derived from E,E-COD, as well as the bacterial wall of Gram-positive Staphylococcus aureus, showing the potential of these linkers for live-cell imaging. Furthermore, these linkers could be conjugated with mAbs such as Rituximab and Obinutuzumab, to show the viability of the method for preparing mAb-constructs.
Matteo Zanda is coauthor of ~210 papers, including 8 patent applications.
Laurea degree in chemistry (1991, UniMI); PhD in industrial chemistry (1998, PoliMI); Postdoc (1999, ULP Strasbourg); Senior Researcher CNR (2001); Personal Chair in Medical Technologies (2009, University of Aberdeen, UK); Chair in Biomolecular Imaging and Director of the Centre for Sensing and Imaging Science (2019, Loughborough University, UK); Research Director CNR (2021, SCITEC Milan, Italy). Editor-in-chief of Synform, Thieme-Chemistry (https://www.thieme.de/en/thieme-chemistry/journals-synform-54850.htm)