RESEARCH ACTIVITY

At CSAN - CNR I carried out my work for research programs of the CNR (as P.I.), of the University "La Sapienza", of the MURST and of the Pasteur Institute-Cenci Bolognetti Foundation, aimed at studying the relationships between structure and functions chromatin by chemical, biochemical, biological molecular and microscopy (TEM and AFM) methods. At the Rome Section of the ICRM, now SCITEC, located at the Institute of Biochemistry and Clinical Biochemistry, of the Catholic University of the Sacred Heart, I deal with: 1- Expression of genes implicated in apoptotic phenomena and oxidative stress in cell cultures and rat or mouse tissue by molecular biology methods; 2- Analysis of telomerase activity by TRAP assay in immortalized cells in the presence of compounds with alleged anti-tumor activity; 3- Analysis by visualization with AFM of the aging of the red blood cell; 4- Analysis of mitochondrial DNA damage.

PROJECTS

Collaborator for CNR-NRC Joint project (Egypt) “Design, synthesis and biological evaluation of new chalcone-based-fibrates as PPAR-a agonists, with Dr Francesca Sciandra as Italian P.I:, (2018-2020). Collaborator for THE NANDO AND ELSA PERETTI FOUNDATION “Individuation of the S100B protein as a therapeutic target in multiple sclerosis pathogenic processes” Prof. Fabrizio Michetti as P.I.

ASI Project “Countermeasures Against space Radiation and Microgravity induced brain lesions (CARM)” with Prof. Sergio Capaccioli as P.I. collaborator to Dr Stefano Cacchione as head of U.R..(2011-2014)

RESEARCH INTERESTS

Structural biology, gene expression, molecular biology, microscopy

SCIENTIFIC SKILLS

Protein and Nucleic Acid extraction, Protein / Nucleic acid bond analysis, Real-timeP CR, TEM and AFM  microscopy, Telomerase activity analysis, Mitochondrial DNA damage analysis.

RESEARCH AREA

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Research Groups

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