My scientific activity aims to develop advanced methods and materials for bio-molecular recognition applied to biomarker discovery and to diagnosis, with a strong focus to system integration and technology development. Applications in healthcare include allergy, infectious diseases, diagnostic signatures for neurodegeneration and inflammation. Quite recently I took an interest on extracellular vesicles towards the prospective of their use in routine diagnostic assays and I’m tackling the currently unmet challenges they pose in terms of isolation and analysis. Specifically I’m working on affinity-capturing protocols from complex samples for isolation and on microarray-based platforms for their structural and molecular characterization More details and updates:
https://www.ctbio.eu/analytical-microsystems-lab-3/ https://www.ctbio.eu/extracellular-vesicles-lab/
PROJECTS
2017-2020 : READy Network REgionAle per lo sviluppo di metodi Diagnostici in risposta rapida a epidemie emergenti e bioemergenze ID 229472 (Regione Lombardia Accordi per la Ricerca e l’Innovazione) Principal Investigator
2016-2017 INDEX — Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes. H2020 FETOPEN Contract n°766466. Staff scientist and Project manager
2019 -2021 : HYDROGEX A Peptide Hydrogel Platform for Extracellular Vesicles Isolation and Multimodal Analysis. Avviso congiunto per la concessione di contributi a sostegno del trasferimento della conoscenza nel settore dei Materiali avanzati; Fondazione Cariplo & Regione Lombardia; rif. 2018-1720. Staff Scientist
2020-2022 : INTERSLA - INnovazione, nuovi modelli TEcnologici e Reti per curare la SLA - ID 1157625 (Regione Lombardia “BANDO Call HUB Ricerca e Innovazione”) Principal Investigator (Coordinatore, responsabile UR.
2020-2022 MARVEL Evolving reversible immunocapture by membrane sensing peptides: towards scalable extracellular vesicles isolation. H2020 FETPROACT-EIC-06-2019 Grant agreement: 951768. Coordinatore.
2010-2015 EU FP7 NADINE Nanosystems for early diagnosis of neurodegenerative diseases Staff scientist
2010-2014 EU FP7 POSITIVE A highly integrated and sensitive PORous SIlicon based lab on a chip for multiple quantitaTIVE monitoring of Food allergies at point of care Staff Scientist
2012-2014: LOCSENS (Innovativa piattaforma basata su microsistemi analitici per il dosaggio rapido della contaminazione batterica e virale in ambienti sensibili) ID 30071637. Principal Investigator
2013-2015: FIRB 2012 Futuro in Ricerca (RBFR12OO1G_003) “Materiali nanoporosi: lavagne autoassemblanti per lo studio della struttura e delle interazioni del DNA (NEMATIC) “. Principal Investigator
RESEARCH INTERESTS
Microanalytical chemistry; Biosensing; Diagnostics; Biomarker validation; Extracellular vesicles;
SCIENTIFIC SKILLS
Development of analytical platforms; Bioconjugation; Surface modification; Advanced sero-profiling by microarrays
RESEARCH AREA
Research Groups
