The research activity is strongly characterized by clinical proteomics studies and development of innovative analytical methods based on liquid chromatography and Capillary Electrophoresis (CE) and Capillary Electrochromatography microanalytical techniques in coupling with mass spectrometry, in the context of national and international scientific collaborations and research projects.
Expertise specifically acquired: i) proteomics and peptidomics of biofluids, tissues and cell cultures, following top-down/bottom-up mass spectrometry integrated platforms: biomarker discovery, bioactive peptides, neuroproteomics, secretome profiling; ii) CE and CEC-UV/MS new methods development for applications of biomedico-clinical, toxicological, food analysis and environmental interest; iii) chiral separations: study of new chiral selectors by CE, chiral pharmaceutical compounds separation, enantiomeric purity evaluation, stereoselective metabolisms.
Author of more than 95 papers on peer reviewed international journals, 3 books chapters, national and international congress communications and invited oral communications.
PROJECTS
Progetto PRIN (MIUR) 2017 - Immunomodulatory properties of the Amniotic Stromal cell SEcretome: from Multi-omics profiling to nanotechnoLogy-aided delivery for controlled release in osteoarthritis – ASSEMbLe – Coordinatore Prof.ssa Ornella Parolini (Università Cattolica) – Responsabile di Unità di Ricerca
Progetto comune di ricerca Bando CNR/CINVESTAV - Identifying dystroglycan binding partners in the cellular nucleus: proteomic analysis of beta-DG nuclear interactors – Coordinatore Andrea Brancaccio (CNR) e Bulmaro Cisneros Vega (CINVESTAV) – Partecipante
-2001-2005: Scientific responsible for the approved research line of the CNR Inst. of Chemical Methodologies (IMC) “Development of capillary electrophoretic and electro chromatographic techniques for biological, pharmaceutical and toxicological separations in complex matrices and biological fluids”
-PRIN Project 2006 - Determinazione (con metodi proteomici) del complesso proteico presente nella secrezione delle ghiandole salivari di mammiferi in varie situazioni fisio- patologiche – PI RIVA Alessandro – Research Unit PI M.Castagnola - Participant.
-Telethon Grant number GGP06170 (2006-2008) - Analysis of candidate genetic regions and peptides and metabolites profile in autism- PI Fiorella Gurrieri – Participant
-Research project of Catholic University – Linea D.1 Roma 2010– Identificazione di biomarcatori dei tumori della fossa cranica posteriore in età pediatrica mediante analisi proteomica del fluido cefalorachidiano – Concezio Di Rocco - Participant
RESEARCH INTERESTS
PROTEOMICS, PEPTIDOMICS, ANALYTICAL CHEMISTRY, MASS SPECTROMETRY
SCIENTIFIC SKILLS
CLINICAL PROTEOMICS, ANALYTICAL METHOD DEVELOPMENT, LIQUID CHROMATOGRAPHY, CAPILLARY ELECTROPHORESIS, CHIRAL SEPARATIONS, MASS SPECTROMETRY
RESEARCH AREA
