Molecular tools and technologies for precision medicine
SCITEC applies a multidisciplinary approach to precision medicine investigations by connecting competences and approaches in analytical chemistry, biochemistry, molecular biology and organic synthesis with computational chemistry and -omics sciences either to develop new technological approaches and new (bio)materials, including hydrogels and nanoparticles, or to investigate the molecular bases of disease onset and progression and their inter-individual variability, to discover biomarkers and new therapeutic targets.
In this perspective it is worthy of mention the increasing prominence of Extracellular Vesicles for their potential role in diagnostics (liquid biopsy), therapies, as drug carriers in delivery, and for regenerative medicine.
Analytical and Bioanalytical Chemistry:
Chromatography, Capillary Electrophoresis, mono-/bi-dimensional electrophoresis, chiral analysis, mass spectrometry, spectroscopy, microarray technology (design, manufacturing, analysis), single molecule ELISA (SIMOA); NMR, X-ray, SQUID, elemental analysis, AFM, TEM, SEM and confocal microscopy
Biochemistry and Molecular Biology:
Analysis of gene expression, real time-PCR, Western-blot, Immunoassays, Cell cultures, production of recombinant proteins, in vitro screening, Proteomics and Peptidomics, Interactomics, Metabolomics
Protein modeling, molecular dynamics simulations, AI driven computer aided drug design, virtual screening and pharmacophore modeling
peptides chemistry, stereoselective sensors, biologically active molecules, fluorescent probes
supramolecular hydrogels, polymeric coatings for surface treatments
synthesis and functionalization
isolation , characterization and engineering