Image

CHEMISTRY FOR LIFE SCIENCES

"Targeting baCteriAl cell eNvelope of Nosocomial paThogens to ESKAPE resistance" - CANNOT-ESKAPE

Abstract: CANNOT-ESKAPE project targets the three most scary multidrug resistant bacteria belonging to the ESKAPE family of pathogens, K. pneumoniae, A. baumannii and P. aeruginosa, which are the leading cause of hospital infections globally and are reported by WHO as the greatest threat to the human health. The goal of the project is to acquire new information on molecular mechanisms of resistance and adaptation of these pathogens to desiccation and last-resort drugs, mediated by a pool of cell envelope modifying enzymes. WP1 will contribute to the structural and biochemical characterisation of a panel of CPS degrading enzymes and of LPS modifying enzymes. The interaction of these enzymes with cell envelope fragments extracted from clinical strains will be studied in WP2 as a tool to develop enzyme inhibitors using computational approaches. Confirmed hits, which will be microbiologically and immunochemically tested in WP3, will provide good starting points for chemical optimization.

Activity : 2022-2025

 

Image

SCITEC ContactBenedetta Righino, Personnel of the CNR research unit

Email benedetta.righino@scitec.cnr.it

We use cookies

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.