The research activities are aimed at studying the molecular basis of the development of muscular dystrophies. Proteins involved in disease development are expressed in cellular models to analyze how pathological mutations affect their function and localization. The main interest is focused at the extracellular matrix proteins and their receptors whose gene expression and regulation are also analyzed in a context of inflammatory stress.
PROJECTS
2018-2020 Bilateral project CNR / NRC Egypt. Role: PI
2019-2021 Bilateral project CNR / CINVESTAV Mexico. PI: Andrea Brancaccio Role: participant
2018-2020 Cystic Fibrosis Research Foundation Project, PI: Maurizio Sanguinetti Role: participant.
2016-2018 French AFM-Telethon Pr. 20009 "Establishing new models for primary dystroglycanopathies" PI Andrea Brancaccio, Role: participant
2012-2015 PRIN Project "Neurodegeneration and neuroprotection: role of the expression of neuroglobin induced by estrogen hormones" PI Paolo Ascenzi, Role: participant
RESEARCH INTERESTS
Biochemistry, Molecular and Cellular Biology
SCIENTIFIC SKILLS
Western-Blot, confocal microscopy, real-time, cell viability assay, promoter activationc assay, immunoprecipitation and solid-phase binding assay).
RESEARCH AREA
