Antimicrobial peptides loaded inhalable calcium phosphates nanoparticles for the counteraction of antibiotic resistance: towards a new therapy for respiratory infections - AppliCare
Abstract: Antibiotic resistance (AMR) is one of the top 10 global public health threats facing humanity. In the last two decades, respiratory bacteria have increasingly becoming resistant to several antibiotics, and the prevalence of resistant strains is growing rapidly. The search for new antibiotic formulations for these infections is therefore a primary objective in the current health context. Antimicrobial peptides (AMPs) are emerging category of therapeutic agents with a huge potential application. The aim of AppliCare is to reach the proof of concept for a new therapeutic formulation based on inhalable and biodegradable calcium phosphate (CaPs) NPs, functionalized with new AMPs providing different advantages: (i) release of molecule in a more specific time and spatial window, and (ii) peptide protection against early degradation.
Activity: Aprile 2022-aprile 2025