Molecular Probes for Early Diagnosis of Neurodegenerative Diseases by 19F Nuclear Magnetic Resonance Techniques
Progetto Bilaterale CNR-MoES Albania
Abstract: New tracers that can deliver 19F to amyloid plaques or detect metabolic brain disorder associated with ND are designed, synthesized ans tested in vitro and in vivo. In particular two sets of tracers, either purely organic and containing metals, are investigated with the aim to maximize the T2/T1 relaxation times of 19F nuclei. These tracers are loaded with the highest possible number of identical 19F nuclei, taking care not to significantly alter the chemistry of the compounds and without increasing their possible toxicity.
Activity : 1/1/2021 - 31/12/2022