CHEMISTRY FOR LIFE SCIENCES Projects
CHEMISTRY FOR LIFE SCIENCES Projects
CHEMISTRY FOR LIFE SCIENCES Projects
CHEMISTRY FOR LIFE SCIENCES
Aggregation modulators of functional amyloids: silk fibroin as an inexpensive model for the investigation of the Alzheimer Disease pathogenesis - AMYLOIDS
Aberrant protein aggregation, such as amyloidogenesis, is associated with many neurodegenerative diseases, such as Alzheimer’s disease. Most proteins can adopt an amyloid state, in which the protein backbone forms a cross-β-sheet structure capable of...
Immunomodulatory properties of the Amniotic Stromal cell SEcretome: from Multi-omics profiling to nanotechnoLogy-aided delivery for controlled release in osteoarthritis - ASSEMbLe
Aim of the project is to provide significant advancements to the knowledge on the molecular complexity underlying the anti-inflammatory/immunomodulatory properties of the secretome of mesenchymal stromal cells isolated from human term placenta...
Antimicrobial peptides loaded inhalable calcium phosphates nanoparticles for the counteraction of antibiotic resistance: towards a new therapy for respiratory infections - AppliCare
Antibiotic resistance (AMR) is one of the top 10 global public health threats facing humanity. In the last two decades, respiratory bacteria have increasingly becoming resistant to several antibiotics, and the prevalence of resistant strains is growing rapidly...
Targeting baCteriAl cell eNvelope of Nosocomial paThogens to ESKAPE resistance" - CANNOT-ESKAPE
CANNOT-ESKAPE project targets the three most scary multidrug resistant bacteria belonging to the ESKAPE family of pathogens, K. pneumoniae, A. baumannii and P. aeruginosa, which are the leading cause of hospital infections globally and are reported by WHO as the greatest...
Revealing the molecular mechanisms of SARS-CoV-2 interaction with membranes to design inhibitors of viral entry and replication
Infection by envelope viruses is mediated by fusion proteins on the virus surface and requires exposure of a fusion peptide (FP), which inserts into the target membrane. SARS-CoV-1 FP contains critical conserved acidic residues, binds calcium ions, and...
Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes - INDEX
The aim of Project INDEX is to isolate and characterize nanoparticles available in bodily fluids through the development and integration of novel technological breakthroughs. The technology will enable the analysis of clinically valuable nanoparticles...
INnovazione, nuovi modelli TEcnologici e Reti per curare la SLA - INTERSLA
INTERSLA si avvale di una consolidata rete di eccellenze in ricerca di base, clinica e industriale in grado di affrontare in modo innovativo il progetto. Obiettivo generale è ampliare la conoscenza della patogenesi della SLA mediante un approccio preclinico-clinico...
Evolving reversible immunocapture by membrane sensing peptides: towards scalable extracellular vesicles isolation - MARVEL
MARVEL mission is to combine and implement reversible capturing and peptide science, towards the first and best performing ever affinity-based technology for scalable small Extracellular Vesicles (EVs) isolation...
Molecular Probes for Early Diagnosis of Neurodegenerative Diseases by 19F Nuclear Magnetic Resonance Techniques
New tracers that can deliver 19F to amyloid plaques or detect metabolic brain disorder associated with ND are designed, synthesized ans tested in vitro and in vivo. In particular two sets of tracers, either purely organic and containing metals, are investigated with the aim to...
Individuation of the S100B protein as a therapeutic target in multiple sclerosis pathogenic processes - NaEPF
S100B is a calcium/zinc-binding protein secreted by mature astrocytes, associated, at high levels, with nervous tissue injury in a variety of neuropathological processes, including Multiple Sclerosis in the acute phase. An increased expression of S100B has been observed...
Glyco-Nanoparticles for Applications in Advanced Nanomedicine - NanoCarb
The advance of nanomedicine requires the development of novel materials with tailored properties, controlled circulation, optimal targeting and therapeutic efficacy after administration. Nanomaterials engineered with glycans offer...
Automated in-line separation and detection of extracellular vesicles for liquid biopsy applications - NEXUS
The NEXUS project will develop an easily customizable integrated platform to enable Extracellular Vesicles (EVs) separation, purification, and multivariate characterization from complex biofluids. EVs enclose a heterogeneous group of cell-released...
Synthesis and biomedical applications of tumor targeting peptidomimetics and conjugates
Peptides are emerging as ideal antitumor drugs, mainly because of their specificity and low off-target effects. The poor pharmacokinetic properties of peptides, including plasma stability, can be overcome by using peptidomimetics, while retaining peptide versatility and feasibility...
Miglioramento delle Produzioni Agroalimentari e Tecnologie Innovative per un’Alimentazione più Sana, Sicura e Sostenibile - Spatials3
Dalla produzione primaria degli alimenti alla trasformazione degli ingredienti, dal packaging alla sicurezza alimentare, passando per la validazione funzionale sull’uomo di prodotti nutrizionalmente innovativi, fino alla creazione di strumenti digitali per...
Targeting the interaction between SARS-CoV-2 and host cells as a potential anti-viral strategy - TRACER
Coronaviruses use specific protein-protein interactions (PPIs) to subvert the host-cell physiology and to promote replication and spreading. This peculiarity can be exploited for the design of anti-viral compounds, as antivirals perturbing PPIs are less prone to resistance...
TRAPping tumor growth: designing molecules to perturb the chaperone TRAP1, from enzymatic activities to cell-cell interaction
Chemical targeting of biomolecular organization to regulate cellular signaling is a fascinating goal. The key challenge is to design chemical tools able to selectively interfere with functional substates, partner interactions, downstream effects of proteins...
Identificazione di nuove molecole con potenziale terapeutico per la cura del virus "Zika" ed altri virus emergenti-Progetto Regione lazio - ZIKA
Le proteine non-strutturali dei Flavivirus rappresentano un target promettente per lo sviluppo di nuove molecole con potenziale terapeutico per la cura del virus Zika. Recentemente numerose informazioni strutturali relative a NS5 metiltransferasi,...